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10.1038/s41467-018-03941-2 44 JonesB.McGloneE

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MCH1R antagonists have also been shown to be efficacious in animal models of depressive behavior although the precise mechanism for the antidepressant effects are not yet clearly defined

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Less frequently reported adverse reactions (less than 1% or less than twice rate of placebo) included abdominal pain upper, dry mouth, weight decreased, dizziness, somnolence, logorrhea, chest pain, anger and hypertension

[79], which compared metformin, clomifene citrate, and pioglitazone, but did not include emerging drug therapies such as GLP-1 RAs and SGLT2is