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van Bommel EJM, Muskiet MHA, van Baar MJB et al (2020) The renal hemodynamic effects of the SGLT2 inhibitor dapagliflozin are caused by post-glomerular vasodilatation rather than pre-glomerular vasoconstriction in metformin-treated patients with type 2 diabetes in the randomized, double-blind RED trial

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coli , 6mGLP-1 demonstrated biological activity in vitro , stimulating proliferation of the mouse insulinoma cell line MIN6 even in the presence of trypsin, and in vivo , lowering blood glucose in diabetic mice

In human cartilage pellet cultures, GLP-1 analogues restored proteoglycan markers suppressed by IL-1