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Patients should be observed carefully for signs and symptoms of pancreatitis (e.g

While numerous proof-of-concept candidate molecules have been disclosed ( and Zepbound ) ( ex vivo finding, the GIPR monoagonist LY3537021 reduced body weight by ~4.1% over 8 weeks in patients with T2D (n = 18) ( 2.2 GIPR agonism serves to reduce GLP-1R mediated GI AEs in the clinic Treatment with GLP-1R agonists can drive nausea, diarrhea, vomiting, and constipation, which often results in discontinuation of treatment (6-10% of patients) or reduction in dose (~15% of patients) ( It has been hypothesized that the deleterious, nauseating effects of GLP-1R agonists and the beneficial, food-intake reducing effects are inextricably linked
Over 100 GLP-1 therapies are currently in active development globally, with approximately 25 candidates in mid-to-late stage trials [41]

Genetic findings should be interpreted with your provider as one factor among manyliver function, age, and concurrent medications also matter significantly

P., et al., ChEMBL: A LargeScale Bioactivity Database for Drug Discovery, Nucleic Acids Research 40, no

doi: 10.1152/ajpgi.00024.2010 [DOI] [PubMed] [Google Scholar] 15