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Statistical analysis We used propensity score matching to create balanced comparison groups and estimate causal effects while controlling for measured confounders (see previous section)

68 In contrast, other large-scale population-based studies have failed to demonstrate a significant increase in intestinal obstruction risk when GLP-1 RAs were compared with SGLT-2 inhibitors

GLP-1 medications such as semaglutide and tirzepatide work by slowing gastric emptying and enhancing satiety hormones, causing most patients to naturally eat significantly less without feeling deprived

In clinical trials, retatrutide was generally introduced with a low starting dose and increased gradually over time

Diagnostic evaluation should include assessment of serum ferritin levels and transferrin saturation, as iron deficiency is a treatable contributing factor