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For instance, in the head-to-head SURMOUNT-5 trial, the rate of discontinuation due to AEs was numerically lower for Tirzepatide (6.1%) compared to semaglutide 2.4 mg (8.0%), although the study was not powered for a formal statistical comparison of safety outcomes

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For instance, bariatric surgery has been shown to reduce the risk of hospitalizations among patients with established HF [25,26,27,28,29]

Likewise, the favorable impact of semaglutide on inflammatory markers such as CRP and NT-proBNP levels might provide further insight into the potential benefit of semaglutide in patients with heart failure with preserved ejection fraction (HFpEF)

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1.1% with dulaglutide 0.75 mg)