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The most direct evidence so far comes from a 2025 study out of UCLA, published in ACR Open Rheumatology

When approved products appear on FDA's Drug Shortage List, certain compounding activities may become permissible under specific circumstances

Injections have been around longer and remain the most widely used option

however, no changes in the low/high frequency ratio were found in the lixisenatide group [18]

The GLP-1 agonists that are currently approved for weight loss are liraglutide (Saxenda) and semaglutide (Wegovy)

This dynamic has played out with semaglutide already, where compounded semaglutide remains popular despite approved versions being available