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Therefore, our current study is consistent with a model where, during HFHC dietinduced metabolic dysregulation, the deletion of Dpp4 within Tie2 + cells increases the abundance of GLP-1 delivered to the systemic circulation, enabling the incretin effect, and improves oral glucose tolerance but does not affect HGP

doi: 10.3389/fendo.2021.721198 101

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*FOR ORAL SEMAGLUTIDE USED FOR TYPE 2 DIABETES SOURCE: American Diabetes Association

This can worsen GLP-1 side effects digestion concerns
