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Tirzepatide may not be appropriate for all patients, and comorbidities can influence response

GLP-1 & Muscle Loss: Do Semaglutide or Tirzepatide Cause Muscle Wasting
They compared people taking tirzepatide to dulaglutide, an older GLP-1 drug predating semaglutide

Take the medication in the morning to minimize insomnia from phentermine stimulant effects

doi: 10.1038/onc.2017.38

Endocr Rev 2021
