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The primary search terms included: NAFLD or NASH or MASLD or MASH AND incretin therapies or GLP-1 receptor agonists or GIP receptor agonists or glucagon receptor agonists or dual agonism or triple agonism

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it has only recently been appreciated that the gut has the capacity to detect intraluminal contents in much the same way as the tongue, via activation of specific G-protein-coupled receptors, and that ensuing signaling mechanisms modulate the release of an array of gut hormones that influence gastrointestinal motility, appetite and glycemia

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Finally, the increasing off-label use of GLP-1 RAs for weight loss in non-diabetic individuals may further exacerbate access limitations and drug shortages, potentially disadvantaging patients with T2DM

Its ability to reduce hepatic glucose production, improve insulin sensitivity, and offer weight neutrality or modest loss has made it a go-to for clinicians