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Currently, another small molecule GLP-1R agonist called compound 29 (DA-302168S) has also shown good therapeutic potential ( in vitro and in vivo with a reduced risk of drug-drug interactions and is undergoing phase 2 clinical trials

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A third, recent study in JAMA Network Open , from August of 2025, analyzed data from 159,000 people with type 2 diabetes who took semaglutide or tirzepatide (Mounjaro, Zepbound)

glp-1 class drugs New Guidelines for Type 2 Diabetes in 2025 GLP-1 Drugs for Weight Loss:

Routine Laboratory Monitoring: While semaglutide doesn't require specific blood test monitoring beyond standard diabetes care, informing your primary care physician ensures appropriate interpretation of glucose, HbA1c, and other metabolic parameters

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Ozempic and other GLP-1 drugs are covered only in specific cases

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