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Tamborlane WV, Barrientos-Prez M, Fainberg U, Frimer-Larsen H, Hafez M, Hale PM et al (2019) Liraglutide in children and adolescents with type 2 diabetes

While the estimates included possible savings from improved health, these were not nearly sufficient to offset the costs of the medications

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The most common reason for discontinuation globally was patient-related GI issues, with 64.4% reporting they caused malaise and 45.4% reporting emesis

Hjerpsted JB, Flint A, Brooks A, Axelsen MB, Kvist T, Blundell J

Protective mucus in the GI tract consists of a sticky, negatively charged mesh that slows the diffusion of large, hydrophilic macromolecules while continuously turning over, thereby pulling material away from the epithelium