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The metabolic rate of GLP-1R KO mice was significantly slower than that of WT mice (p=0.0345, WT mice 0.023350.057mM/min, GLP-1R KO mice 0.019980.07mM/min)

Results The search strategy identified 833 hits, of which 42 studies were included in the final review

As a result, many members turned to diabetes-indicated GLP-1s off-label, creating shortages that impacted patients who needed them for type 2 diabetes