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IL-23 sits upstream and regulates the broader immune response

By identifying genetic variants that influence drug metabolism, transport, and target sensitivity, pharmacogenomics offers key insights into variability in drug efficacy and toxicity [15]

Thus, oral administration of a peptide therapeutic represents a significant advance in medicine, but is challenged by gastrointestinal instability and ineffective uptake into the circulation

Although biased agonism is now recognized for some of these agonists, there is still insufficient information on the broad pharmacodynamics properties of these drugs to differentiate the contribution of biased agonism from pharmacokinetic behavior to differential clinical responses, side effects, or toxicities, although this is likely to be an important consideration in future therapeutic development

What reduction in BMI SDS is required in obese adolescents to improve body composition and cardiometabolic health

[cited 2023 Nov 17]