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High-molecular-weight GLP-1 RAs, such as dulaglutide and albiglutide (not approved in Japan), exert their weight-reducing effects presumably due to limited brain penetration [59,60,61] (Fig

#SGLT2i #Ketogenesis #CardioMetabolic #KidneyDisease #LiverMetabolism To view or add a comment, sign in How might SGLT2 inhibitors mediate cardiorenal benefits beyond glucose lowering

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Compounded versus FDA-approved safety considerations: Compounded GLP-1 medications are not FDA-approved

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For Dr Sinclair, the unknowns of the knock-off retatrutide are the primary concern