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Instead, they are considering overall cardiometabolic health

Survodutide Phase II trial shows 83% of adults treated achieved groundbreaking results in liver disease due to MASH, with significant improvements in fibrosis

Under EMA approval pathways and NICE single-technology appraisal, multi-indication platforms command different HTA architecture than single-indication assets, especially under the new EU JCA framework starting June 2026

Given the established physiological effects of GIP receptor activation, GIP receptor antagonism could potentially lead to undesirable increases in blood glucose levels due to reduced insulin secretion
