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Semaglutide, a GLP*1 receptor agonist, reduces appetite via GLP*1 receptors in the hypothalamus and increases the production, and reduces glucagon secretion, delaying gastric emptying

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Strategies could include dosing rapid-acting insulins 30-minutes after the start of eating (instead of the typical 15 minutes before meals), or split-bolus dosing, whereby a patient takes 50% of their rapid acting insulin before a meal, and 50% 30-minutes after the start of a meal