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Description
Reduced levels of certain sirtuins resulting from decreased nicotinamide adenine dinucleotide (NAD+) may underlie the dysregulation of the aforementioned signaling pathways and therefore represent a potential therapeutic target

Consistent reductions were seen for patients stratified by gender, age group, race and in patients with and without T2D

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In contrast, no benefits on the rate of decline in glomerular filtration rate have been seen in trials of DPP-4 inhibitors, perhaps because the renal actions of DPP-4 inhibitors are primarily mediated by potentiation of SDF-1, not GLP-1
