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Comparative performance of two quantitative safety signalling methods: implications for use in a pharmacovigilance department

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GLP-1 medications for weight loss (with and without diabetes) While GLP-1 medications were originally developed to treat type 2 diabetes, it has become clear that their effects on appetite regulation and satiety can lead to substantial weight loss even in people who do not have diabetes

Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression

However, a national Blue Health Intelligence study from the Blue Cross Blue Shield Association finds that more than 30% of patients dropped out of treatment after the first four weeks and 58% of patients taking the medications for weight loss discontinued use before seeing a clinical benefit