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Medication-specific patterns The STEP UP trial reported that 22.9% of people on Wegovy 7.2 mg experienced dysaesthesia, including tingling, numbness, or other abnormal skin sensations

While precise current user numbers vary by data source, IQVIA tracking shows substantial year-over-year growth, though supply constraints and insurance coverage limitations continue to affect access

In the STEP-1 and STEP-5 studies, semaglutide 2.4 mg led to the restoration of normoglycemia in 84% and 80% of subjects with prediabetes (compared to 48% and 37% in the control group), respectively after 68 and 104 weeks of treatment, and reduced the risk of progression to T2D [53]

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The FDA has approved peptide-based drugs continuously for decades across oncology, metabolic disease, hormone disorders, and rare conditions, and the global market for peptide therapeutics was valued at $140.9 billion in 2025 (more on Grand View Research)

Alongside medication, a diet based on whole foods rich in soluble fibre, oily fish, vegetables, and lean protein supports cholesterol levels and healthy weight loss