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doi: 10.3390/biom13121695 29

Repeated cycles of initiation, interruption and re-initiation of these drugs might induce body weight and HbA 1c fluctuations two risk factors for cardiovascular and microvascular events

16 Matthias Tschp and his team discovered that dual agonists targeting both GLP-1 and GIP receptors (GIPR) are more effective in treating diabetes than those targeting only GLP-1R

This is referred to as metabolic adaptation, which reduces GLP-1 and GIP levels and increases the orexigenic hormone ghrelin

Renal outcomes were explored in a prespecified secondary analysis [30]

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