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Binge eating can lead to obesity and insulin resistance, increasing the likelihood of developing diabetes

This example underscores a broader point: not all underexplored peptides need to become drugs to influence drug discovery

In the ATTAIN-MAINTAIN trial, orforglipron's profile was "consistent with previous orforglipron Phase 3 studies." The most common adverse events were gastrointestinal-related and were generally mild-to-moderate in severity, which is expected for the GLP-1 class

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Retatrutides most impressive results come from a 48-week Phase 2 study, while Cagrisemas data primarily reflects 32-week outcomes

Common side effects include nausea, vomiting, diarrhoea, abdominal pain, and reduced appetite, especially when starting or increasing the dose