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The TSH-lowering effect of metformin was observed in patients with overt hypothyroidism and subclinical hypothyroidism, but not in euthyroid patients [98,99]

Beyond metabolic slowing, patients may experience fluid retention, decreased fat breakdown, and alterations in appetite-regulating hormones

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Comparison of the GLP-1R sequences in human and monkey versus other species revealed the notable presence of a tryptophan (W) at position 33 of the primate GLP-1R

Typically, the natural GLP-1 hormone breaks down quickly, but semaglutide is designed to resist this breakdown, allowing it to work for a longer period