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Supplementary Table S2 (21)]

The glucagon component increases energy expenditure and fat oxidation, a mechanism unique to retatrutide that semaglutide (GLP-1 only) and tirzepatide (GLP-1/GIP) lack

This is the maximum safe dose that the FDA has approved
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Systemic injection of Ex-4 was also able to evoke reduced cocaine seeking by activating GLP-1R in the NAc and the VTA [66,67]
