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2 GLP-1R monotherapy (e.g., semaglutide) is highly effective, but dual GLP-1R/GIPR agonists (e.g.,

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### Competing Interest Statement ASK, AMM, MCG, JMD, CB, CL, SWB, DJL, PML, DRD, JMC, JPF, YL, ARS, DAT, DWP, SH, RBR, MSL, and DAG are employees and stockholders of Pfizer Inc

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