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A major new clinical trial is putting a spotlight on one of the biggest conversations in medicine right now: what happens when GLP-1based therapy is brought into psoriatic arthritis care

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When cultured human L-cells were deprived overnight of glucose and serum and then exposed to high glucose, 10% FBS, and -carrageenan (1g/ml) for 10minutes, 1h, and 24h, mRNA expression of proglucagon and secretion of GLP-1 were significantly reduced, compared to control cells not exposed to carrageenan

FDA warning letters

'(Semaglutide)'

Some studies, though not conclusive, predict that tirzepatide may in fact be more potent than GLP-1 RAs at reducing weight