what to know before starting semaglutide for weight loss | Blog What to Expect After First

BPC-157 may support tissue recovery, but it does not build strength

As such, I strongly counsel my patients to eat plenty of high-quality protein, like chicken, fish, and shellfish, or soy, beans, and legumes if theyre vegetarian, to ensure they experience as little muscle wasting as possible

Aim for at least 2 litres of water daily

The 2026 Allergan Aesthetics healthcare provider survey (March 4, 2026 press release) reported 61% of GLP-1 patients experiencing midface volume loss, 50% experiencing skin laxity, and 35% experiencing facial wrinkles or folds as their primary aesthetic concerns

The discontinuation rate due to side effects in participants with a BMI of 35 or higher was 12.1% at the 12mg dose, a figure that clinicians have called acceptable given the level of weight loss achieved

Finally, oral administration of the nonnutritive sweetener, Dallulose, was found to selectively increase active GLP1 in the hepatic portal vein without altering the levels of other gut hormones (Iwasaki et al., 2018)