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Manufacturer guidance recommends caution or discontinuation during breastfeeding, reflecting the precautionary principle rather than proven harm

This helps to ensure minimal post-operative bruising and swelling

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Keep the vial protected from direct light

Moreover, adipose tissue macrophages in obesity adopt a pro-inflammatory M1 phenotype, further amplifying systemic immune activation, whereas weight reduction favors a switch toward an anti-inflammatory M2 phenotype [39]

Doctors usually start patients on a low dose, increasing it every four weeks to minimize side effects