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More than a decade later, in 2005, exenatide (a synthetic version of exendin-4) was approved as the first anti-diabetes medication in the GLP-1 receptor agonist class by the U.S

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These systems typically employ temperature- or pH-sensitive biodegradable polymers that form viscoelastic depots in situ, facilitating controlled release of therapeutic agents such as GLP-1 receptor agonists while circumventing systemic toxicity [45]

doi: 10.1016/j.bmcl.2015.12.024

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