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Clinical Pharmacology & Therapeutics, 53(3), 324-328

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Eye 16 , 440446 (2002)

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Drug Interactions The concomitant use of JANUMET with specific drugs may increase the risk of metformin-associated lactic acidosis: those that impair renal function, result in significant hemodynamic change, interfere with acid-base balance or increase metformin accumulation [see Drug Interactions (7)]

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