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Sulfonylureas vs Incretin Mimetics: Key Differences Sulfonylureas and incretin mimetics (GLP-1 receptor agonists) are two fundamentally different classes of glucose-lowering medications used to manage type 2 diabetes mellitus

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Consequently, GIP and GLP-1 receptor agonists exhibit complementary and potentially synergistic actions, suggesting that their combined administration may further enhance glucose regulation and support weight reduction.1113,50 This rationale underpins the development of dual GLP-1/GIP receptor agonists, which have been proposed as super-GLP-1 receptor agonists because of GIPs capacity of GIP to potentiate GLP-1 effects.48,51 Clinical Pharmacology of GLP-1RAs The incretin effect of GLP-1RAs was initially characterized by the observation that oral glucose administration elicits a proportionally greater and more sustained insulin secretion compared to an equivalent intravenous glucose dose.52,53 This incretin effect, which accounts for approximately two-thirds of the total insulin secretion during an oral glucose tolerance test, is diminished in individuals with T2DM

Perioperative management of patients taking glucagon-like peptide-1 receptor agonists: Applying evidence to clinical practice