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50 50 & Target IC50: 3.22 nM (glucagon-like peptide-1 receptor) [1] In Vitro In human umbilical vein endothelial cells, exendin-4 significantly increases NO production, endothelial NO synthase (eNOS) phosphorylation, and GTP cyclohydrolase 1 (GTPCH1) level in a dose-dependent manner [2]
Lancet, 397 (10278), 971984
