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The combined effect can make you feel uncomfortably distended and puffy, even when you have not overeaten

This approach can significantly extend the life of each vial, reducing monthly costs

The placebo group gave back fifteen percent, about twenty-eight pounds, and most of them needed rescue medication along the way

This is particularly important for patients taking tirzepatide alongside sulfonylureas or insulin, as dose adjustments of these medications may be necessary

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Researchers then randomized 670 participants to take either tirzepatide or placebo for another 52 weeks (double blinded)