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Description
Liu L., Chen J., Wang L., Chen C., and Chen L., Association Between Different GLP1 Receptor Agonists and Gastrointestinal Adverse Reactions: A RealWorld Disproportionality Study Based on FDA Adverse Event Reporting System Database, Frontiers in Endocrinology 13 (2022): 1043789

Without baseline labs and medication review, side effects or interactions can be missed, and titration can become unsafe

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this is considered the most likely primary contributor Possible natriuretic effects linked to GLP-1 receptor activation, which may promote renal sodium excretion observed with other GLP-1 receptor agonists but not yet directly demonstrated for retatrutide in humans [4] Potential improvements in endothelial function associated with reduced systemic inflammation and insulin resistance again, a hypothesis extrapolated from the wider drug class Glucagon receptor activity , which may influence cardiac output and vascular tone
