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While some studies found no effect on GLP-1 levels post-alcohol intake, others noted reductions in heavy drinkers

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451 Quignot, N

In opposite to ghrelin, GLP-1 agonism appears to reduce caloric intake by preferentially targeting consumption of both fat and sugar-rich palatable foods

Furthermore, GLP-1RAs downregulate pro-apoptotic proteins such as Bax and cleaved caspase-3 while enhancing anti-apoptotic proteins like Bcl-2 through the combined action of cAMP-PKA, PI3K/Akt, and CREB signaling pathways (as indicated by broken lines in Figure 4), thereby promoting neuronal survival and protecting against apoptosis [51]

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