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Without Phase II, every Phase I metabolite would accumulate as a free radical, causing more damage than the original toxin

doi: 10.1089/ars.2012.4508

Nutrients commonly associated with cognitive resilience include omega-3 fatty acids (particularly DHA), magnesium, vitamin D, zinc, polyphenols, and compounds such as curcumin and resveratrol, which may support mitochondrial function and neuronal signaling

On the contrary, several analyses suggest that there is an increase of mitochondrial fragmentation in AD (Figure 2A), that have been ascribed to A toxicity (Wang et al., 2008b, 2009b, 2017)

10.1038/nature23007 221 VukoviA.-M.Bosello TravainV.BordinL.CozzaG.MiottoG.RossettoM.et al (2020)

CSF and Blood Oxytocin Concentration Changes following Intranasal Delivery in Macaque