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Strong evidence supports their efficacy in inducing clinically meaningful weight loss in individuals with overweight or obesity

17 In addition to these findings, the SUSTAIN-6 trial also showed that semaglutide can offer a significant reduction in the risk of new or worsening nephropathy including persistent macroalbuminuria, increase in serum creatinine or the need of renal replacement therapy

wrote the paper

J., Chen, N., Makhijani, P., Winer, S., Furman, D., & Winer, D

Further, despite internal resistance at Novo, Knudsen initiated trials administering a higher dose of liraglutide (Saxenda) for the treatment of obesity

Cardiovasc Diabetol 3:1521