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In this review, we summarize the state-of-the-art evidence regarding the epidemiology and pathophysiology of diabetic HFpEF, and the landscape of the novel antidiabetic drugs in the treatment of diabetic HFpEF, as well as discuss the relevant mechanisms, aiming to broaden the understanding of diabetic HFpEF and gain new insight into the treatment of this disease

Losing too much of it may compromise metabolic flexibility and longevity

Glucagon-like peptide-1 (GLP-1)is an incretin hormonealso classified as a gut-derived peptidesecreted by intestinal L-cells in response to nutrient ingestion, particularly carbohydrates and fats
