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In human adipocytes, tirzepatide exposure results in an increase in both mRNA expression and LPL activity, as well as increased fatty acid uptake into adipocytes

This level of restriction, even if unintentional, risks serious nutritional deficits and may indicate that your current tirzepatide dose needs adjustment

The ER knockout mice had a greater reduction in visceral fat mass, which can suggest that ER activation may oppose oestrogens lipolytic effects mediated by ER activation [16,39,41]

JAMA Oncol

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