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This is especially relevant in the case of semaglutide, given its structural similarity to the natural GLP-1 hormone present in milk, compounded by the potential for early infant satiety with drug exposure

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The retinal capillary damage central to DR leads to tissue hypoxia, altered venous oxygen saturation, and a compromised ability to regulate blood flow [87,88,89]

In such mice, exendin-4 exerts its normal action to potentiate GSIS and to improve glucose tolerance in the absence of neural GLP-1R activation