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In addition, the current review reveals the IGF-1 and GLP-1 activators based on the premise that the restoration of abnormal IGF-1/GLP-1 signaling could result in neuroprotection and neurotrophic effects for the clinical-pathological presentation of ALS and other brain diseases
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Similar results have been found in the more recent STEP-HFpEF DM trial, that analyzed the effects of subcutaneous semaglutide in a population with the same inclusion criteria but also presenting with T2D
