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Double Incretin Receptor Knockout (DIRKO) Mice DIRKO mice have normal body weight and do not have improved glycaemic response following exogenous administration of GIP or the GLP-1R agonist exendin-4

doi: 10.1136/bmj.d7771

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nevertheless, the mechanism by which it works has yet to be elucidated

Instead of ice packs, they use polymer crystals that activate with water
