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Based on Phase 2 trial data (Jastreboff et al., NEJM 2023), retatrutide's side effect profile appears broadly consistent with other GLP-1-based therapies, though the addition of glucagon receptor agonism introduces some distinct considerations

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It can cross the BBB and influence pituitary release of gonadotropins, thereby affecting hormone levels

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Abstract Understanding of gustatory coding helps to predict, and perhaps even modulate the ingestive decision circuitry, especially when eating behaviour becomes dysfunctional