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This unique presentation of both NAWE and TIND in a single patient following GLP-1 agonist use warrants careful consideration of the potential central and peripheral neurological sequelae of these increasingly prevalent medications and emphasizes the need for heightened clinical awareness and appropriate monitoring strategies

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Unlike appetite suppressants, SLU-PP-332s metabolic effects are observed without reductions in food intake and without increased spontaneous activity, indicating a primary action on metabolic programing rather than behavior

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A second experimental approach under study is the use of glucagon, with delivery from a pump triggered by CGM sensor glucose data