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Although this has key benefits in treating type 2 diabetes, the metabolism-slowing effect also makes it easier for patients without diabetes to stick to a diet

While tirzepatide made history as the first dual GIP/GLP-1 receptor agonist to receive FDA approval, retatrutide pushes the pharmacological envelope further with triple receptor agonism that adds glucagon receptor activation

Targeting the GLP-1/GLP-1R Axis to Treat Osteoarthritis: A New Opportunity

Gradually increasing fibre from whole foods can help, but adding too much fibre at once can make things worse

The study did not find similar optic nerve risks with drugs such as Mounjaro or Zepbound, which use a different mechanism

doi: 10.1016/j.bcp.2014.10.015
