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But profound, persistent weakness that worsens over weeks, particularly muscle-specific weakness that makes daily activities difficult, can indicate excessive lean tissue catabolism

Finally, we conducted subgroup analyses by sex and obesity status, demonstrating generally consistent associations across strata, and we implemented an exposure lag period to reduce potential reverse causality, collectively strengthening the credibility of the observed associations

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Stronger documentationincluding documented weight trajectory, obesity-related comorbidities, or diabetes control metricsimproves approval likelihood

And if you increase your muscle mass, youll burn more calories, even at rest