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[1] [2] The mechanism of action involves activating both GIP and GLP-1 receptors, which reduces appetite, slows gastric emptying, and improves glycemic control

However, retatrutide does not currently hold UK marketing authorisation, and access remains restricted to registered clinical trials

Commonly, users report dry mouth, increased heart rate, elevated blood pressure, insomnia, restlessness, jitteriness, headache, dizziness, and constipation

Abrupt discontinuation may lead to sharp blood sugar changes, rapid appetite increases, and emotional frustration from unexpected weight regain

GERD affects around 15-20% of the UK population