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Dehydration from vomiting or loose stools is dangerous and incompatible with GLP-1 therapy, which already reduces oral intake

The study strictly adhered to the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines and was conducted following the national regulations for the ethical use and care of laboratory animals

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Each mouse underwent individual placement in a tank for 6 min

Weight loss results Tirzepatide produces greater average weight loss

In the LEAD-6 clinical study, which lasted for 26 weeks, the efficacy of liraglutide with background metformin and/or sulfonylurea therapy was compared with that of twice-daily exenatide6)