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Ursodiol prophylaxis, careful dose titration, and regular symptom monitoring are reasonable precautions
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The NHS generally recommends a gradual weight loss of 0.5-1 kg per week as being more sustainable and potentially less likely to result in significant skin laxity
Some people find it hard to stay awake during the day, which can affect their daily activities
However, their wealth of pleiotropic actions soon raised expectations that they might confer benefits on non-metabolic disorders
