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GLP-1 receptor agonists are crucial in managing type 2 diabetes and obesity due to their diverse effects

This medication helps reduce appetite and supports weight loss, but once it is discontinued, its effects may diminish as the bodys natural appetite and metabolism return to their previous state

Losing weight is a very individualized process the "best" medication for you depends on several factors

Maintaining lost weight long-term is harder than losing it initially

GLP-1 analogues are all injectable therapies, which may be a drawback for some patients, although oral semaglutide is in development and was recently approved by the US Food and Drug Administration

In preclinical models, direct activation of GLP-1Rs in the NTS reduces food and drug intake, whereas knockdown of GLP-1R in this region reverses these effects [20,35]