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To minimize discomfort, increase intake gradually and drink enough water throughout the day
If you inject in the thigh in the evening, you are combining the slowest absorption site with sleep

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doi:10.1185/03007995.2011.590127 49

The process now requires that the PRAC send its recommendations and assessment to the Committee for Medicinal Products for Human Use (CHMP), which will likely adopt PRACs opinion

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